Akụkọ banyere iwu cannabis na United States bụ ihe akaebe maka ngwá agha ndọrọ ndọrọ ọchịchị nke Ngalaba Ikpe Ziri Ezi, yana mmekọrịta dị mgbagwoju anya n'etiti amụma ọgwụ ọjọọ, ịkpa ókè agbụrụ na ikpe na-ezighị ezi. Site na mmụọ ọjọọ mbụ ya ruo n'oge mgbasa ozi ọha na eze, cannabis nwere njikọ chiri anya na mgbagwoju anya nke esemokwu agbụrụ na ikpe na-ezighị ezi. Edemede a na-enyocha ọnọdụ akụkọ ihe mere eme nke iwu cannabis, na-enyocha ka mmụọ ọjọọ siri metụta ụmụ amaala US, ọkachasị ụmụ nwoke America sitere na Africa.
Enwere ike ị nweta mmalite nke iwu cannabis ịkpa oke na kọmishọna Harry Anslinger. Otu nwoke ụfọdụ ndị ọkọ akụkọ ihe mere eme na-akpọ "nna na-akpa oke agbụrụ nke mmachi ọgwụ ọjọọ". Anslinger siri ọnwụ na ejiri cannabis jikọtara ya na egwu Jazz na United States, n'oge na-adịghị anya, ịkpa ókè agbụrụ malitere ịpụta na-akpụzi echiche ọha na eze banyere osisi na ụmụ nwoke Africa.
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